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Publications
137. Kovalenko OV, Metcalf DG, Degrado WF, Hemler
ME.
Structural
organization and interactions of transmembrane domains in tetraspanin proteins.
BMC Struct Biol. 2005 Jun 28;5(1):11 [Epub ahead of print] PubMed Full
Text
136. Xu D, Hemler ME.
Metabolic activation-related CD147-CD98 complex.
Mol Cell Proteomics. 2005 May 18; [Epub ahead of print] PubMed Full
Text
135. Yang X, Kovalenko OV, Tang W, Claas C, Stipp
CS, Hemler ME
Palmitoylation supports
assembly and function of integrin-tetraspanin complexes.
J Cell Biol. 2004
Dec 20;167(6):1231-40. PubMed Full
Text
134. Tang
W, Chang SB, Hemler ME
Links
between CD147 function, glycosylation, and caveolin-1.
Mol Biol Cell. 2004
Sep;15(9):4043-50. PubMed Full
Text
133. Kolesnikova TV,
Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME
EWI-2
modulates lymphocyte integrin alpha4beta1 functions.
Blood. 2004 Apr 15;103(8):3013-9. PubMed Full
Text
132. Little KD, Hemler
ME, Stipp CS
Dynamic
regulation of a GPCR-tetraspanin-G protein complex on intact cells: central
role of CD81 in facilitating GPR56-Galpha q/11 association.
Mol Biol Cell.
2004 May;15(5):2375-87. PubMed Full
Text
131. Tang W, Hemler ME
Caveolin-1
regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell
surface clustering.
J Biol Chem. 2004 Mar 19;279(12):11112-8. PubMed Full
Text
130. Stipp CS, Kolesnikova
TV, Hemler ME
EWI-2
regulates alpha3beta1 integrin-dependent cell functions on laminin-5.
J Cell
Biol. 2003 Dec 8;163(5):1167-77. PubMed Full
Text
129. Kovalenko
OV, Yang X, Kolesnikova TV, Hemler ME
Evidence
for specific tetraspanin homodimers: inhibition of palmitoylation makes
cysteine residues available for cross-linking.
Biochem J. 2004 Jan 15;377(Pt
2):407-17. PubMed Full
Text
128. Lammerding
J, Kazarov AR, Huang H, Lee RT, Hemler ME
Tetraspanin
CD151 regulates alpha6beta1 integrin adhesion strengthening.
Proc Natl Acad
Sci U S A. 2003 Jun 24;100(13):7616-21. PubMed PDF
127. Kazarov
AR, Yang X, Stipp CS, Sehgal B, Hemler ME
An
extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6
integrin-dependent cellular morphology.
J Cell Biol. 2002 Sep 30;158(7):1299-309. PubMed Full Text
126. Yang X, Claas C, Kraeft
SK, Chen LB, Wang Z, Kreidberg JA, Hemler ME
Palmitoylation
of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular
distribution, and integrin-dependent cell morphology.
Mol Biol Cell. 2002
Mar;13(3):767-81. PubMed Full
Text
125. Zhang XA, Kazarov
AR, Yang X, Bontrager AL, Stipp CS, Hemler ME
Function
of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.
Mol
Biol Cell. 2002 Jan;13(1):1-11. PubMed Full
Text
124. Kolesnikova TV,
Mannion BA, Berditchevski F, Hemler ME.
Beta1
integrins show specific association with CD98 protein in low density membranes.
BMC
Biochem. 2001;2(1):10. PubMed Full
Text
123. Stipp CS, Kolesnikova TV,
Hemler ME
EWI-2
is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.
J
Biol Chem. 2001 Nov 2;276(44):40545-54. PubMed Full
Text
122. Zhang XA, Bontrager
AL, Hemler ME
Transmembrane-4
superfamily proteins associate with activated protein kinase C (PKC) and
link PKC to specific beta(1) integrins.
J Biol Chem. 2001 Jul 6;276(27):25005-13. PubMed Full
Text
121. Sun J, Hemler ME
Regulation of MMP-1 and MMP-2 production through CD147/extracellular
matrix metalloproteinase inducer interactions.
Cancer Res. 2001 Mar 1;61(5):2276-81.PubMed Full
Text
120. Zhang XA, Bontrager
AL, Stipp CS, Kraeft SK, Bazzoni G, Chen LB, Hemler ME
Phosphorylation of a
conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and
cytoskeletal engagement.
Mol Biol Cell. 2001 Feb;12(2):351-65. PubMed Full
Text
119. Claas C, Stipp CS, Hemler ME
Evaluation of prototype
transmembrane 4 superfamily protein complexes and their relation to lipid
rafts.
J Biol Chem. 2001 Mar 16;276(11):7974-84. PubMed Full
Text
118. Stipp CS, Orlicky D, Hemler ME
FPRP, a major, highly stoichiometric,
highly specific CD81- and CD9-associated protein.
J Biol Chem. 2001 Feb 16;276(7):4853-62. PubMed Full
Text
117. Yauch RL, Hemler ME
Specific interactions among transmembrane 4 superfamily
(TM4SF) proteins and phosphoinositide 4-kinase.
Biochem J. 2000 Nov 1;351 Pt
3:629-37. PubMed Full
Text
116. Stipp CS, Hemler ME
Transmembrane-4-superfamily
proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively
contribute to alpha 3 beta 1-dependent neurite outgrowth.
J Cell Sci. 2000 Jun;113
( Pt 11):1871-82. PubMed Full
Text
115. Yauch RL, Kazarov AR,
Desai B, Lee RT, Hemler ME
Direct extracellular contact
between integrin alpha(3)beta(1) and TM4SF protein CD151.
J Biol Chem. 2000
Mar 31;275(13):9230-8. PubMed Full
Text
114. Tachibana I, Hemler
ME
Role of transmembrane 4
superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube
maintenance.
J Cell Biol. 1999 Aug 23;146(4):893-904. PubMed Full
Text
113. Seipel K, Medley QG,
Kedersha NL, Zhang XA, O'Brien SP, Serra-Pages C, Hemler ME, Streuli M
Trio
amino-terminal guanine nucleotide exchange factor domain expression promotes
actin cytoskeleton reorganization, cell migration and anchorage-independent
cell growth.
J Cell Sci. 1999 Jun;112 ( Pt 12):1825-34. PubMed PDF
112. Zhang XA, Hemler ME
Interaction of the integrin
beta1 cytoplasmic domain with ICAP-1 protein.
J Biol Chem. 1999 Jan 1;274(1):11-9. PubMed Full
Text
111. Mannion
BA, Kolesnikova TV, Lin SH, Wang S, Thompson NL, Hemler ME
The
light chain of CD98 is identified as E16/TA1 protein.
J Biol Chem. 1998 Dec
11;273(50):33127-9. PubMed Full Text
110. Yauch RL, Berditchevski
F, Harler MB, Reichner J, Hemler ME
Highly stoichiometric,
stable, and specific association of integrin alpha3beta1 with CD151 provides
a major link to phosphatidylinositol 4-kinase, and may regulate cell migration.
Mol
Biol Cell. 1998 Oct;9(10):2751-65. PubMed Full
Text
109. Crommie D, Hemler ME
Beta1 integrin cytoplasmic
domain regulates the constitutive conformation detected by MAb 15/7, but
not the ligand-induced conformation.
J Cell Biochem. 1998 Oct 1;71(1):63-73. PubMed Full
Text
108. Eble JA, Wucherpfennig KW, Gauthier L, Dersch
P, Krukonis E, Isberg RR, Hemler ME
Recombinant soluble human alpha 3 beta 1 integrin: purification,
processing, regulation, and specific binding to laminin-5 and invasin in
a mutually exclusive manner
Biochemistry. 1998 Aug 4;37(31):10945-55. PubMed
107. Bazzoni G, Ma L, Blue
ML, Hemler ME
Divalent cations and ligands
induce conformational changes that are highly divergent among beta1 integrins.
J
Biol Chem. 1998 Mar 20;273(12):6670-8. PubMed Full
Text
106. Hemler ME, Lobb RR
The leukocyte beta 1 integrins.
Curr Opin Hematol. 1995 Jan;2(1):61-7. PubMed
105. Pujades C, Alon R,
Yauch RL, Masumoto A, Burkly LC, Chen C, Springer TA, Lobb RR, Hemler ME
Defining
extracellular integrin alpha-chain sites that affect cell adhesion and adhesion
strengthening without altering soluble ligand binding.
Mol Biol Cell. 1997 Dec;8(12):2647-57. PubMed Full
Text
104. Tachibana I, Bodorova
J, Berditchevski F, Zutter MM, Hemler ME
NAG-2, a novel transmembrane-4
superfamily (TM4SF) protein that complexes with integrins and other TM4SF
proteins.
J Biol Chem. 1997 Nov 14;272(46):29181-9. PubMed Full
Text
103. Berditchevski F, Chang
S, Bodorova J, Hemler ME
Generation of monoclonal
antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes
with EMMPRIN/basigin/OX47/M6
J Biol Chem. 1997 Nov 14;272(46):29174-80. PubMed Full
Text
102. Yauch RL, Felsenfeld
DP, Kraeft SK, Chen LB, Sheetz MP, Hemler ME
Mutational evidence for
control of cell adhesion through integrin diffusion/clustering, independent
of ligand binding
J Exp Med. 1997 Oct 20;186(8):1347-55. PubMed Full
Text
101. Berditchevski F, Tolias
KF, Wong K, Carpenter CL, Hemler ME
A novel link between integrins,
transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol
4-kinase.
J Biol Chem. 1997 Jan 31;272(5):2595-8. PubMed Full
Text
100. Weitzman JB, Pujades
C, Hemler ME
Integrin alpha chain cytoplasmic
tails regulate "antibody-redirected" cell adhesion, independently
of ligand binding.
Eur J Immunol. 1997 Jan;27(1):78-84. PubMed
99. Yuan Q, Strauch KL, Lobb RR, Hemler ME
Intracellular single-chain
antibody inhibits integrin VLA-4 maturation and function.
Biochem J. 1996 Sep
1;318 ( Pt 2):591-6. PubMed Full
Text
98. Mannion BA, Berditchevski
F, Kraeft SK, Chen LB, Hemler ME
Transmembrane-4 superfamily
proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with
integrin alpha 4 beta 1 (CD49d/CD29).
J Immunol. 1996 Sep 1;157(5):2039-47. PubMed Full
Text
97. Bazzoni G, Carlesso
N, Griffin JD, Hemler ME
Bcr/Abl expression stimulates
integrin function in hematopoietic cell lines.
J Clin Invest. 1996 Jul 15;98(2):521-8. PubMed Full
Text
96. Weitzman JB, Hemler
ME, Brodt P
Reduction of tumorigenicity
by alpha 3 integrin in a rhabdomyosarcoma cell line.
Cell Adhes Commun. 1996
Jul;4(1):41-52. PubMed
95. Berditchevski F, Zutter
MM, Hemler ME
Characterization of novel
complexes on the cell surface between integrins and proteins with 4 transmembrane
domains (TM4 proteins)
Mol Biol Cell. 1996 Feb;7(2):193-207. PubMed Full
Text
94. Pujades C, Teixido J,
Bazzoni G, Hemler ME
Integrin alpha 4 cysteines
278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180
formation.
Biochem J. 1996 Feb 1;313 ( Pt 3):899-908. PubMed Full
Text
93. Weitzman JB, Chen A,
Hemler ME
Investigation of the role
of beta 1 integrins in cell-cell adhesion.
J Cell Sci. 1995 Nov;108 ( Pt 11):3635-44. PubMed Full
Text
92. Bazzoni G, Shih DT,
Buck CA, Hemler ME
Monoclonal antibody 9EG7
defines a novel beta 1 integrin epitope induced by soluble ligand and manganese,
but inhibited by calcium.
J Biol Chem. 1995 Oct 27;270(43):25570-7. PubMed Full
Text
91. Berditchevski F, Bazzoni
G, Hemler ME
Specific association of
CD63 with the VLA-3 and VLA-6 integrins.
J Biol Chem. 1995 Jul 28;270(30):17784-90. PubMed Full
Text
90. Schiffer SG, Hemler
ME, Lobb RR, Tizard R, Osborn L.
Molecular mapping of functional
antibody binding sites of alpha 4 integrin.
J Biol Chem. 1995 Jun 16;270(24):14270-3. PubMed Full
Text
89. Kassner PD, Alon R,
Springer TA, Hemler ME
Specialized functional
properties of the integrin alpha 4 cytoplasmic domain.
Mol Biol Cell. 1995 Jun;6(6):661-74. PubMed Full
text
88. Bergelson JM, Hemler
ME
Integrin-ligand binding.
Do integrins use a 'MIDAS touch' to grasp an Asp?
Curr Biol. 1995 Jun 1;5(6):615-7. PubMed
87. Alon R, Kassner PD, Carr MW, Finger EB, Hemler
ME, Springer TA
The integrin VLA-4 supports
tethering and rolling in flow on VCAM-1
J Cell Biol. 1995 Mar;128(6):1243-53. PubMed Full
Text
86. Lee RT, Berditchevski F, Cheng GC, Hemler ME
Integrin-mediated collagen
matrix reorganization by cultured human vascular smooth muscle cells.
Circ Res.
1995 Feb;76(2):209-14. PubMed Full
Text
85. Lobb RR, Hemler ME
The pathophysiologic role
of alpha 4 integrins in vivo.
J Clin Invest. 1994 Nov;94(5):1722-8. PubMed Full
Text
84. Bergelson JM, St John
NF, Kawaguchi S, Pasqualini R, Berdichevsky F, Hemler ME, Finberg RW
The I domain
is essential for echovirus 1 interaction with VLA-2
Cell Adhes Commun. 1994
Oct;2(5):455-64. PubMed
83. Kawaguchi S, Bergelson
JM, Finberg RW, Hemler ME
Integrin alpha 2 cytoplasmic
domain deletion effects: loss of adhesive activity parallels ligand-independent
recruitment into focal adhesions.
Mol Biol Cell. 1994 Sep;5(9):977-88. PubMed Full
Text
82. Kassner PD, Kawaguchi
S, Hemler ME
Minimum alpha chain cytoplasmic
tail sequence needed to support integrin-mediated adhesion.
J Biol Chem. 1994
Aug 5;269(31):19859-67. PubMed Full
Text
81. Potts AJ, Croall DE, Hemler ME
Proteolytic cleavage of
the integrin beta 4 subunit.
Exp Cell Res. 1994 May;212(1):2-9. PubMed
80. Pasqualini R, Hemler
ME
Contrasting roles for integrin
beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation,
and cell migration.
J Cell Biol. 1994 Apr;125(2):447-60. PubMed Full
Text
79. Masumoto A, Hemler
ME
Mutation of putative divalent
cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects
on adhesion to CS1/fibronectin, VCAM-1, and invasin.
J Cell Biol. 1993 Oct;123(1):245-53. PubMed Full
Text
78. Kawaguchi S, Hemler
ME
Role of the alpha subunit
cytoplasmic domain in regulation of adhesive activity mediated by the integrin
VLA-2.
J Biol Chem. 1993 Aug 5;268(22):16279-85. PubMed Full
Text
77. Mihich E, Hemler ME
Adhesion molecules: cellular
recognition mechanisms. The Pezcoller Foundation Symposia, Rovereto, June
24-26, 1992.
Ann Oncol. 1993 Aug;4(7):545-7 PubMed
76. Kassner PD, Hemler
ME
Interchangeable alpha chain
cytoplasmic domains play a positive role in control of cell adhesion mediated
by VLA-4, a beta 1 integrin.
J Exp Med. 1993 Aug 1;178(2):649-60. PubMed Full
Text
75. Bergelson JM, Chan
BM, Finberg RW, Hemler ME
The integrin VLA-2 binds
echovirus 1 and extracellular matrix ligands by different mechanisms.
J Clin
Invest. 1993 Jul;92(1):232-9. PubMed Full
Text
74. Hemler
M, Mihich E
Fourth annual Pezcoller
Symposium–adhesion molecules: cellular recognition mechanisms.
Cancer Res.
1993 May 1;53(9):2192-4. PubMed
73. Pasqualini R, Bodorova
J, Ye S, Hemler ME
A study of the structure,
function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal
antibodies.
J Cell Sci. 1993 May;105 ( Pt 1):101-11. PubMed Full
Text
72. Weitzman JB, Pasqualini
R, Takada Y, Hemler ME.
The function and distinctive
regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic
cell aggregation.
J Biol Chem. 1993 Apr 25;268(12):8651-7. PubMed Full
Text
71. Parker CM, Pujades
C, Brenner MB, Hemler ME
Alpha 4/180, a novel form of the integrin alpha 4 subunit.
J Biol Chem. 1993
Apr 5;268(10):7028-35. PubMed Full
Text
70. Masumoto A, Hemler
ME
Multiple activation states
of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and
to vascular cell adhesion molecule-1.
J Biol Chem. 1993 Jan 5;268(1):228-34. PubMed Full
Text
69. Chan BM, Hemler ME
Multiple functional forms
of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion
of forms induced by an anti-beta 1 antibody.
J Cell Biol. 1993 Jan;120(2):537-43. PubMed Full
Text
68. Campanero MR, Arroyo
AG, Pulido R, Ursa A, de Matias MS, Sanchez-Mateos P, Kassner PD, Chan
BM, Hemler ME, Corbi AL, et. al.
Functional role of alpha
2/beta 1 and alpha 4/beta 1 integrins in leukocyte intercellular adhesion
induced through the common beta 1 subunit.
Eur J Immunol. 1992 Dec;22(12):3111-9. PubMed
67. Teixido J, Hemler ME,
Greenberger JS, Anklesaria P
Role of beta
1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow
stroma.
J Clin Invest. 1992 Aug;90(2):358-67. PubMed Full
Text
66. Chan BM, Elices MJ, Murphy E, Hemler ME
Adhesion to vascular cell
adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4)
and alpha 4 beta 7 on the human B cell line JY.
J Biol Chem. 1992 Apr 25;267(12):8366-70. PubMed Full
Text
65. Bergelson JM, Shepley
MP, Chan BM, Hemler ME, Finberg RW
Identification of the integrin
VLA-2 as a receptor for echovirus 1.
Science. 1992 Mar 27;255(5052):1718-20. PubMed
64. Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper
TS, Hemler ME
Distinct cellular functions
mediated by different VLA integrin alpha subunit cytoplasmic domains.
Cell.
1992 Mar 20;68(6):1051-60. PubMed
63. Teixido J, Parker CM,
Kassner PD, Hemler ME
Functional and structural
analysis of VLA-4 integrin alpha 4 subunit cleavage.
J Biol Chem. 1992 Jan 25;267(3):1786-91. PubMed Full
Text
62. Hemler ME, Kassner
PD, Chan BM
Functional roles for integrin
alpha subunit cytoplasmic domains.
Cold Spring Harb Symp Quant Biol. 1992;57:213-20. PubMed
61. Kassner PD, Teixido
J, Chan BM, Parker CM, Hemler ME
Analyses of VLA-4 structure
and function.
Adv Exp Med Biol. 1992;323:163-70. PubMed
60. Neuhaus H, Hu MC, Hemler
ME, Takada Y, Holzmann B, Weissman IL
Cloning and expression
of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion
molecule.
J Cell Biol. 1991 Nov;115(4):1149-58. PubMed Full
Text
59. Schiro JA, Chan BM,
Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS
Integrin
alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen
matrices by human cells.
Cell. 1991 Oct 18;67(2):403-10. PubMed
58. Takada Y, Murphy E,
Pil P, Chen C, Ginsberg MH, Hemler ME
Molecular cloning and expression
of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin
receptor for fibronectin, laminin, and collagen.
J Cell Biol. 1991 Oct;115(1):257-66. PubMed Full
Text
57. Chan BM, Wong JG, Rao A, Hemler ME
T cell receptor-dependent, antigen-specific
stimulation of a murine T cell clone induces a transient, VLA protein-mediated
binding to extracellular matrix.
J Immunol. 1991 Jul 15;147(2):398-404. PubMed Full
Text
Pulido R, Elices MJ,
Campanero MR, Osborn L, Schiffer S, Garcia-Pardo A, Lobb R, 56. Hemler ME,
Sanchez-Madrid F
Functional evidence for three distinct and independently
inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation
with distinct alpha 4 epitopes.
J Biol Chem. 1991 Jun 5;266(16):10241-5. PubMed Full
Text
55. Chan BM, Matsuura N, Takada Y, Zetter BR, Hemler
ME
In
vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells.
Science.
1991 Mar 29;251(5001):1600-2. PubMed
54. Elices MJ, Urry LA, Hemler ME
Receptor functions for the
integrin VLA-3: fibronectin, collagen, and laminin binding are differentially
influenced by Arg-Gly-Asp peptide and by divalent cations.
J Cell Biol. 1991
Jan;112(1):169-81. PubMed Full
Text
53. Hemler ME, Elices MJ,
Chan BM, Zetter B, Matsuura N, Takada Y
Multiple ligand binding
functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin
family.
Cell Differ Dev. 1990 Dec 2;32(3):229-38. PubMed
52. Ramaswamy H, Hemler
ME
Cloning, primary structure
and properties of a novel human integrin beta subunit.
EMBO J. 1990 May;9(5):1561-8. PubMed Full
Text
51. Hemler ME, Elices MJ,
Parker C, Takada Y
Structure of the integrin
VLA-4 and its cell-cell and cell-matrix adhesion functions.
Immunol Rev. 1990
Apr;114:45-65. PubMed
50. Elices MJ, Osborn L, Takada Y, Crouse C,
Luhowskyj S, Hemler ME, Lobb RR
VCAM-1 on activated endothelium
interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin
binding site.
Cell. 1990 Feb 23;60(4):577-84. PubMed
49. Hemler ME
VLA proteins in the integrin
family: structures, functions, and their role on leukocytes.
Annu Rev Immunol.
1990;8:365-400. PubMed
48. Elices MJ, Hemler ME
The human integrin VLA-2
is a collagen receptor on some cells and a collagen/laminin receptor on others.
Proc
Natl Acad Sci U S A. 1989 Dec;86(24):9906-10. PubMed Full
Text
47. Kennel SJ, Foote LJ,
Falcioni R, Sonnenberg A, Stringer CD, Crouse C, Hemler ME
Analysis of the tumor-associated
antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily.
J
Biol Chem. 1989 Sep 15;264(26):15515-21. PubMed Full
Text
46. Bank I, Hemler M, Brenner MB, Cohen D, Levy
V, Belko J, Crouse C, Chess L
A novel monoclonal antibody,
1B3.1, binds to a new epitope of the VLA-1 molecule.
Cell Immunol. 1989 Sep;122(2):416-23. PubMed
45. Takada Y, Hemler ME
The primary structure of
the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to
other integrins and the presence of a possible collagen-binding domain.
J Cell
Biol. 1989 Jul;109(1):397-407. PubMed Full
Text
44. Takada Y, Elices MJ,
Crouse C, Hemler ME
The primary structure of
the alpha 4 subunit of VLA-4: homology to other integrins and a possible
cell-cell adhesion function.
EMBO J. 1989 May;8(5):1361-8. PubMed Full
Text
43. Hemler ME, Crouse
C, Sonnenberg A
Association of the VLA
alpha 6 subunit with a novel protein. A possible alternative to the common
VLA beta 1 subunit on certain cell lines.
J Biol Chem. 1989 Apr 15;264(11):6529-35. PubMed Full
Text
42. Heino J, Ignotz RA,
Hemler ME, Crouse C, Massague J
Regulation of cell adhesion
receptors by transforming growth factor-beta. Concomitant regulation of integrins
that share a common beta 1 subunit.
J Biol Chem. 1989 Jan 5;264(1):380-8. PubMed Full
Text
41. Takada Y, Wayner EA,
Carter WG, Hemler ME
Extracellular matrix receptors,
ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3
in the VLA family of heterodimers.
J Cell Biochem. 1988 Aug;37(4):385-93. PubMed
40. Fingerman E, Hemler
ME
Regulation of proteins
in the VLA cell substrate adhesion family: influence of cell growth conditions
on VLA-1, VLA-2, and VLA-3 expression.
Exp Cell Res. 1988 Jul;177(1):132-42. PubMed
39. Hemler ME, Crouse
C, Takada Y, Sonnenberg A
Multiple very late antigen
(VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin
receptor), and VLA-6 structures.
J Biol Chem. 1988 Jun 5;263(16):7660-5. PubMed Full
Text
38. Hemler ME
Adhesive protein receptors
on hematopoietic cells.
Immunol Today. 1988 Apr;9(4):109-13. PubMed
37. Saltini C, Hemler
ME, Crystal RG
T lymphocytes compartmentalized
on the epithelial surface of the lower respiratory tract express the very
late activation antigen complex VLA-1.
Clin Immunol Immunopathol. 1988 Feb;46(2):221-33. PubMed
36. Hemler ME, Huang C,
Takada Y, Schwarz L, Strominger JL, Clabby ML
Characterization of the
cell surface heterodimer VLA-4 and related peptides.
J Biol Chem. 1987 Aug 25;262(24):11478-85. PubMed Full
Text
35. Hemler ME, Jacobson
JG
Cell matrix adhesion-related
proteins VLA-1 and VLA-2: regulation of expression on T cells.
J Immunol. 1987
May 1;138(9):2941-8. PubMed Full
Text
34. Takada Y, Strominger
JL, Hemler ME
The very late antigen family
of heterodimers is part of a superfamily of molecules involved in adhesion
and embryogenesis.
Proc Natl Acad Sci U S A. 1987 May;84(10):3239-43. PubMed Full
Text
33. Takada Y, Huang C,
Hemler ME.
Fibronectin receptor
structures in the VLA family of heterodimers.
Nature. 1987 Apr 9-15;326(6113):607-9. PubMed
32. Hemler ME, Huang C,
Schwarz L
The VLA protein family.
Characterization of five distinct cell surface heterodimers each with a common
130,000 molecular weight beta subunit.
J Biol Chem. 1987 Mar 5;262(7):3300-9. PubMed Full
text
31. Pischel KD, Hemler
ME, Huang C, Bluestein HG, Woods VL Jr.
Use
of the monoclonal antibody 12F1 to characterize the differentiation antigen
VLA-2.
J Immunol. 1987 Jan 1;138(1):226-33. PubMed Full
Text
30. Hemler ME, Glass D,
Coblyn JS, Jacobson JG
Very late activation antigens
on rheumatoid synovial fluid T lymphocytes. Association with stages of T
cell activation.
J Clin Invest. 1986 Sep;78(3):696-702. PubMed Full
Text
29. Hemler ME, Jacobson
JG, Strominger JL
Biochemical characterization
of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells.
J Biol Chem.
1985 Dec 5;260(28):15246-52. PubMed Full
Text
28. Hafler DA, Hemler
ME, Christenson L, Williams JM, Shapiro HM,
Strom TB, Strominger JL, Weiner
HL
Investigation of in vivo
activated T cells in multiple sclerosis and inflammatory central nervous
system diseases.
Clin Immunol Immunopathol. 1985 Nov;37(2):163-71. PubMed
27. Hemler ME, Jacobson
JG, Brenner MB, Mann D, Strominger JL
VLA-1: a T cell surface
antigen which defines a novel late stage of human T cell activation.
Eur J Immunol.
1985 May;15(5):502-8. PubMed
26. Hemler ME, Sanchez-Madrid
F, Flotte TJ, Krensky AM, Burakoff SJ, Bhan AK, Springer TA, Strominger JL
Glycoproteins
of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic
relation to components on resting cells and T cell lines.
J Immunol. 1984 Jun;132(6):3011-8. PubMed
25. Peters PM, Kamarck
ME, Hemler ME, Strominger JL, Ruddle FH
Genetic and biochemical
characterization of human lymphocyte cell surface antigens. The A-1A5 and
A-3A4 determinants.
J Exp Med. 1984 May 1;159(5):1441-54. PubMed Full
Text
24. Hemler ME, Brenner
MB, McLean JM, Strominger JL
Antigenic stimulation regulates
the level of expression of interleukin 2 receptor on human T cells.
Proc Natl
Acad Sci U S A. 1984 Apr;81(7):2172-5. PubMed Full
Text
23. Hemler ME, Malissen
B, Rebai N, Liabeuf A, Mawas C, Kourilsky FM, Strominger JL
A 55,000 Mr surface
antigen on activated human T lymphocytes defined by a monoclonal antibody.
Hum
Immunol. 1983 Oct;8(2):153-65. PubMed
22. Haynes BF, Harden
EA, Telen MJ, Hemler ME, Strominger JL, Palker TJ, Scearce RM, Eisenbarth
GS
Differentiation of human
T lymphocytes. I. Acquisition of a novel human cell surface protein (p80)
during normal intrathymic T cell maturation.
J Immunol. 1983 Sep;131(3):1195-200. PubMed Full
Text
21. Hemler ME, Ware CF,
Strominger JL
Characterization of a novel
differentiation antigen complex recognize by a monoclonal antibody (A-1A5):
unique activation-specific molecular forms on stimulated T cells.
J Immunol.
1983 Jul;131(1):334-40. PubMed Full
Text
20. Burakoff SJ, Clayberger
C, Hemler M, Krensky AM, Reiss CS, Robbins E, Sanchez-Madrid F, Springer
TA, Strominger JL, Ware CF
Cytotoxic T cells directed
against HLA-DR antigens and their surface proteins.
Diagn Immunol. 1983;1(3):116-9. PubMed
19. Hemler ME, Strominger
JL
Monoclonal antibodies reacting
with immunogenic mycoplasma proteins present in human hematopoietic cell
lines.
J Immunol. 1982 Dec;129(6):2734-8. PubMed Full
Text
18. Peters PG, Kamarck
ME, Hemler ME, Strominger JL, Ruddle FH
Genetic and biochemical
characterization of a human surface determinant on somatic cell hybrids:
the 4F2 antigen.
Somatic Cell Genet. 1982 Nov;8(6):825-34. PubMed
17. Hemler ME, Strominger
JL
Characterization of antigen
recognized by the monoclonal antibody (4F2): different molecular forms on
human T and B lymphoblastoid cell lines.
J Immunol. 1982 Aug;129(2):623-8. PubMed Full
Text
16. Haynes BF, Reisner
EG, Hemler ME, Strominger JL, Eisenbarth GS
Description of monoclonal
antibody defining an HLA allotypic determinant that includes specificities
within the B5 cross-reacting group.
Hum Immunol. 1982 Jul;4(4):273-85. PubMed
15. Haynes BF, Hemler
M, Cotner T, Mann DL, Eisenbarth GS, Strominger JL, Fauci AS
Characterization
of a monoclonal antibody (5E9) that defines a human cell surface antigen
of cell activation.
J Immunol. 1981 Jul;127(1):347-51. PubMed Full
Text
14. Irigoyen OH, Rizzolo
PV, Thomas Y, Hemler ME, Shen HH, Friedman SM, Strominger JL, Chess L
Dissection
of distinct human immunoregulatory T-cell subsets by a monoclonal antibody
recognizing a cell surface antigen with wide tissue distribution.
Proc Natl
Acad Sci U S A. 1981 May;78(5):3160-4. PubMed Full
Text
13. Haynes BF, Hemler
ME, Mann DL, Eisenbarth GS, Shelhamer J, Mostowski HS, Thomas CA, Strominger
JL, Fauci AS
Characterization of a monoclonal
antibody (4F2) that binds to human monocytes and to a subset of activated
lymphocytes.
J Immunol. 1981 Apr;126(4):1409-14. PubMed Full
Text
12. Cotner T, Hemler M,
Strominger JL
Human T cell proteins recognized
by rabbit heteroantisera and monoclonal antibodies.
Int J Immunopharmacol. 1981;3(3):255-68. PubMed
11. Reiss CS, Hemler ME, Englehard VH, Mier JW,
Strominger JL, Burakoff SJ
Development and characterization of allospecific long-term human cytolytic
T-cell lines.
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5432-6. PubMed Full
Text
10. Hemler ME, Lands WE
Evidence for a peroxide-initiated
free radical mechanism of prostaglandin biosynthesis.
J Biol Chem. 1980 Jul
10;255(13):6253-61. PubMed Full
Text
9. Hemler ME, Lands WE
Protection of cyclooxygenase
activity during heme-induced destabilization.
Arch Biochem Biophys. 1980 May;201(2):586-93. PubMed
8. Haynes BF, Mann DL,
Hemler ME, Schroer JA, Shelhamer JH, Eisenbarth GS, Strominger JL, Thomas
CA, Mostowski HS, Fauci AS
Characterization of a monoclonal
antibody that defines an immunoregulatory T cell subset for immunoglobulin
synthesis in humans.
Proc Natl Acad Sci U S A. 1980 May;77(5):2914-8. PubMed Full
Text
7. Hemler ME, Cook HW,
Lands WE
Prostaglandin biosynthesis
can be triggered by lipid peroxides.
Arch Biochem Biophys. 1979 Apr 1;193(2):340-5
6. Hemler ME, Graff G,
Lands WE
Accelerative autoactivation
of prostaglandin biosynthesis by PGG2.
Biochem Biophys Res Commun. 1978 Dec
29;85(4):1325-31. PubMed
5. Hemler ME, Crawford
CG, Lands WE
Lipoxygenation activity
of purified prostaglandin-forming cyclooxygenase.
Biochemistry. 1978 May 2;17(9):1772-9. PubMed
4. Dawson MI, Reid M,
Hemler ME, Lands WE
Synthesis of prostaglandin
synthetase substrate analogues. 2. (8Z,11Z,14Z)-15-Methyl-8,11,14-eicosatrienoic
acid.
J Med Chem. 1977 Nov;20(11):1396-400 PubMed
3. Yeh CL, Dawson M, Hemler ME, Lands WE.
Synthesis of (8Z, 14Z)-13,13-dimethyleicosa-8,14-dien-11-ynoic
acid as an inhibitor of prostaglandin cyclooxygenase
Tetrahedron Letters 1977. 18:4257-4260
2. Hemler ME, Lands WE
Biosynthesis of prostaglandins.
Lipids. 1977 Jul;12(7):591-5. PubMed
1. Hemler M, Lands WE
Purification of the cyclooxygenase
that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.
J
Biol Chem. 1976 Sep 25;251(18):5575-9. PubMed Full
Text
Selected reviews
Hemler ME
Tetraspanin proteins mediate cellular penetration, invasion,
and fusion events and define a novel type of membrane microdomain.
Annu Rev Cell Dev Biol. 2003;19:397-422. PubMed PDF
Stipp CS, Kolesnikova TV, Hemler ME
Functional domains in tetraspanin proteins.
Trends Biochem Sci. 2003 Feb;28(2):106-12. PubMed
Hemler ME
Specific tetraspanin functions.
J Cell Biol. 2001 Dec 24;155(7):1103-7. PubMed Full
Text
Hemler ME
Retooling of the beta 4 integrin in tumor cells--ligands
lost and kinase gained
Dev Cell. 2001 Dec;1(6):728-30. PubMed
Hemler ME, Rutishauser U
Cell-to-cell contact and extracellular matrix.
Curr Opin Cell Biol. 2000 Oct;12(5):539-41. PubMed
Hemler ME
Dystroglycan versatility.
Cell. 1999 May 28;97(5):543-6. PubMed
Hemler ME
Integrin associated proteins.
Curr Opin Cell Biol. 1998 Oct;10(5):578-85. PubMed
Bazzoni G, Hemler ME
Are changes in integrin affinity and conformation overemphasized?
Trends Biochem Sci. 1998 Jan;23(1):30-4 PubMed
Hemler ME, Mannion BA, Berditchevski F
Association of TM4SF proteins with integrins: relevance
to cancer.
Biochim Biophys Acta. 1996 Jun 7;1287(2-3):67-71. PubMed